Generalized argyria from topical silver sulfadiazine cream application, however, has only been reported in small number of There are numerous internet websites that encourage the ingestion ofĬolloidal silver for various health reasons (one such website can be found at: ). Colloidal silver dietary supplements have been promoted as a panacea for the prevention and treatment of HIV, cancer,ĭiabetes, and herpes infections, among other diseases. Īrgyria can occur in a variety of ways, although most commonly associated with excessive and prolonged ingestion of silver Wounds (such as decubiti), burns and MRSA or Pseudomonas infected lesions.
#SILVADENE CREAM SKIN#
To be utilized in burn victims and patients with widely denuded skin as an effective anti-pseudomonal topical antibiotic.īecause of its antimicrobial properties, silver-impregnated dressings have recently been introduced for the treatment of open Silver sulfadiazine cream has been used for many decades and continues Silver compounds are used widely as antimicrobial agents. Based on physical exam findings and laboratory data, the patient was diagnosed withĪrgyria from chronic application of silver sulfadiazine cream. 2) A serum silver level was obtainedĪnd found to be 130mcg/L (normal≤5mcg/L). 1) He had amputated digits, scarring, and short stature, consistent with EB. On physical examination, the patient had a striking a diffuse slate-gray pigmentation, particularly prominent on the face. Typical features of dystrophic epidermolysis bullosa can be appreciated. Diffuse slate-gray pigmentation, most prominent on foreheadįigure 2. Of the latter medications has been associated with cutaneous dyschromia.įigure 1. The patient was also taking cetirizine, enalapril, and diphenhydramine at the time of consultation. Since then both the patient and his mother have consistently been applying this agent to all affected areasĢ-3 times a day. That time his mother was instructed to apply silver sulfadiazine (Silvadene®) cream to denuded areas on a regular basis to
![silvadene cream silvadene cream](http://drugline.org/img/drug/silver-sulfadiazine-21240_1.jpg)
The patient was diagnosed with EB at birth when he was noted to have tense blisters on his hands.
![silvadene cream silvadene cream](https://www.omniordering.com/images/silvadene%20cream.jpg)
In a patient with epidermolysis bullosa has not previously been reported in the medical literature.Ī 23-year-old male with known recessive dystrophic epidermolysis bullosa (EB) developed diffuse silvery gray pigmentation To our knowledge, argyria resulting from topical application of silver sulfadiazine cream The argyria was confirmedīy an elevated serum silver level. We describe a 23-year-old patient with recessive dystrophic epidermolysisīullosa (EB) who developed generalized argyria from the use of topical silver sulfadiazine cream. It occurs most commonlyįollowing protracted ingestion of commercially purchased or homemade colloidal silver, and much less commonly from the systemicĪbsorption of topical medicines containing silver. The rather unique case of development of argyria following application of silver sulfadiazine in a patient with epidermolysisĪrgyria is an uncommon dermatosis in which the skin and mucous membranes develop a silvery-gray color. AbstractĪrgyria is most commonly reported in association with prolonged ingestion of silver-containing medicaments. John C Browning MD, Moise L Levy MD Dermatology Online Journal 14 (4): 9 Department of Dermatology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.
![silvadene cream silvadene cream](https://www.doomandbloom.net/wp-content/uploads/2017/04/silvadene.png)
Argyria attributed to silvadene application in a patient with dystrophic epidermolysis bullosa